Folic acid
Berocca Pn, Folic Acid, Folvron, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vitaped (folic acid) is a small molecule pharmaceutical. Folic acid was first approved as Folvron on 1982-01-01. It is used to treat folic acid deficiency and megaloblastic anemia in the USA. It is known to target proton-coupled folate transporter and reduced folate transporter.
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2Y
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| hemic and lymphatic diseases | D006425 |
| nutritional and metabolic diseases | D009750 |
Trade Name
FDA
EMA
Folic acid (discontinued: Folic acid, Folicet, Folvite)
CombinationsInfuvite (discontinued: Berocca pn, Folvron, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Folic acid
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Ferrous sulfate
+
Folic acid
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| FOLVRON | Lederle Laboratories | N-006012 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 2 pack assured instant hand sanitizer with moisturizers (vitamin e and aloe) | OTC monograph not final | 2014-11-02 |
| 3 hand sanitizers | OTC monograph not final | 2014-11-15 |
| 3 pack assured instant hand sanitizer with moisturizers (vitamin e and aloe) | OTC monograph not final | 2014-11-02 |
| 3 pack assured instant hand sanitizer with moisturizers (vitamin e and moisturizers) | OTC monograph not final | 2014-11-02 |
| 3 pack family dollar instant hand sanitizers | OTC monograph not final | 2014-11-28 |
| adult infuvite multiple vitamins | New Drug Application | 2025-08-18 |
| advance hand sanitizer moisturizing formula with aloe and vitamin e | OTC monograph not final | 2020-01-01 |
| allevia | unapproved drug other | 2025-02-27 |
| altrufuel hand sanitizer with vitamin e and aloe vera moisturizing formula | OTC monograph not final | 2020-05-22 |
| animi-3 | unapproved drug other | 2013-02-06 |
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B03: Antianemic preparations
— B03A: Iron antianemic preparations
— B03AD: Iron in combination with folic acid
— B03AD01: Ferrous amino acid complex and folic acid
— B03AD02: Ferrous fumarate and folic acid
— B03AD03: Ferrous sulfate and folic acid
— B03AD04: Ferric oxide polymaltose complexes and folic acid
— B03AD05: Ferrous gluconate and folic acid
— B03AE: Iron in other combinations
— B03AE01: Iron, vitamin b12 and folic acid
— B03AE02: Iron, multivitamins and folic acid
— B03B: Vitamin b12 and folic acid
— B03BB: Folic acid and derivatives as antianemics
— B03BB01: Folic acid
— B03BB51: Folic acid, combinations
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01B: Antimetabolites
— L01BA: Folic acid analogs, antimetabolites
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CX: Other diagnostic agents in atc
— V04CX02: Folic acid
HCPCS
No data
Clinical
Clinical Trials
2966 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | — | 12 | 8 | 1 | 1 | 22 |
| Neoplasms | D009369 | — | C80 | 2 | 2 | 7 | 1 | 1 | 12 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | 2 | 4 | 2 | — | 9 |
| Hepatitis | D006505 | — | K75.9 | — | — | 3 | 1 | 2 | 6 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | — | 3 | 1 | 2 | 6 |
| Hepatitis c | D006526 | — | B19.2 | — | — | 3 | 1 | 1 | 5 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | 1 | 2 |
| Communicable diseases | D003141 | — | — | — | — | — | 1 | 1 | 2 |
| Cytomegalovirus infections | D003586 | EFO_0001062 | B25 | — | — | — | 1 | — | 1 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | — | 1 | — | 1 |
Show 5 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 3 | 1 | — | — | 4 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | — | 3 | — | 1 | 4 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | 3 | — | — | 3 |
| Colonic neoplasms | D003110 | — | C18 | — | 1 | 1 | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 1 | — | — | 2 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 1 | — | 1 | — | — | 2 |
| Sclerosis | D012598 | — | — | — | — | 2 | — | — | 2 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | 1 | — | 1 | 2 |
| Melanoma | D008545 | — | — | — | — | 1 | — | — | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | 1 | — | — | 1 |
Show 7 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rectal neoplasms | D012004 | — | — | — | 3 | — | — | — | 3 |
| Adenocarcinoma | D000230 | — | — | 1 | 3 | — | — | — | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 2 | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 2 | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 2 | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | — | 2 | — | — | — | 2 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | 1 | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
| Follicular lymphoma | D008224 | — | C82 | — | 1 | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
Show 4 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | — | — | — | 1 | 2 |
| Covid-19 | D000086382 | — | U07.1 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Bronchiolitis obliterans syndrome | D000092122 | — | D89.811 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 3 | 3 |
| Human influenza | D007251 | EFO_0007328 | J11.1 | — | — | — | — | 2 | 2 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 2 | 2 |
| Hepatitis b | D006509 | — | — | — | — | — | — | 1 | 1 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 1 | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | — | — | — | — | 1 | 1 |
| Uterine hemorrhage | D014592 | — | — | — | — | — | — | 1 | 1 |
| Postmenopause | D017698 | — | — | — | — | — | — | 1 | 1 |
Show 12 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Folic acid |
| INN | folic acid |
| Description | Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing and storage. Folate is required for the body to make DNA and RNA and metabolise amino acids necessary for cell division. As the human body cannot make folate, it is required in the diet, making it an essential nutrient. It occurs naturally in many foods. The recommended adult daily intake of folate in the U.S. is 400 micrograms from foods or dietary supplements.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc(=O)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 59-30-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1622 |
| ChEBI ID | 27470 |
| PubChem CID | 6037 |
| DrugBank | DB00158 |
| UNII ID | 935E97BOY8 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLC46A1
SLC46A1
SLC19A1
SLC19A1
Organism
Homo sapiens
Gene name
SLC46A1
Gene synonyms
G21, HCP1, PCFT
NCBI Gene ID
Protein name
proton-coupled folate transporter
Protein synonyms
Heme carrier protein 1, PCFT/HCP1, solute carrier family 46 (folate transporter), member 1, Solute carrier family 46 member 1
Uniprot ID
Mouse ortholog
Slc46a1 (52466)
proton-coupled folate transporter (Q9D1P1)
Variants
No data
Financial
Revenue by drug
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€
£
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Estimated US medical usage
Folic acid
+
Cholecalciferol
Total medical expenditures per year (USD, in millions)
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Folic acid
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Chromagen, Citranatal, Citranatal 90 dha, Citranatal assure, Citranatal dha, Citranatal essence, Citranatal harmony, Citranatal harmony 2.1, Citranatal harmony 3.0, Citranatal medley, Citranatal rx, Enlyte, Ferralet 90, Healthy mamabe well rounded, Hematogen fa, Hematogen forte, Irospan 24/6, Marnatal f, Menatrol, Moms choice rx, Natafort, Nestabs, Nestabs dha, Nestabs one, Niferex, O-cal prenatal vitamin, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-dha, Pnv-omega, Pnv-select, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Pre-tabs dha, Prenata, Prenatal plus multivitamin plus dha minicaps, Prenatal plus vitamins, Prenatal vitamins plus low iron, Prenate am, Prenate dha, Prenate elite, Prenate enhance, Prenate essential, Prenate mini, Prenate pixie, Prenate restore, Prenatrix, Prenatryl, Prenatryl prometa, Pretrate, Prometa, Select ob, Select-ob plus dha, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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29,436 adverse events reported
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