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AboutPricing
Drug ReportsFolic acid
Folic acid
Berocca Pn, Folic Acid, Folvron, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vitaped (folic acid) is a small molecule pharmaceutical. Folic acid was first approved as Folvron on 1982-01-01. It is used to treat folic acid deficiency and megaloblastic anemia in the USA. It is known to target proton-coupled folate transporter and reduced folate transporter.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
hemic and lymphatic diseasesD006425
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Folic acid (discontinued: Folic acid, Folicet, Folvite)
Combinations
Infuvite (discontinued: Berocca pn, Folvron, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
BEROCCA PNRocheN-006071 DISCN1985-10-10
1 products
Hide discontinued
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE ADULTSandozN-021163 RX2000-05-18
2 products, RLD, RS
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE PEDIATRICSandozN-021265 RX2001-02-21
1 products, RLD, RS
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)SandozN-021265 RX2004-01-29
1 products, RLD, RS
Folic acid
Tradename
Company
Number
Date
Products
FOLIC ACIDEli LillyN-006135 DISCN1982-01-01
1 products
FOLVITEWyethN-005897 DISCN1982-01-01
2 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.C. 9+3APP PharmaceuticalsN-018440 DISCN1985-08-08
1 products
M.V.I.-12 ADULTHospiraN-008809 DISCN1985-08-08
2 products
MVC PLUSAllerganN-018439 DISCN1985-08-08
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 ADULTHospiraN-008809 DISCN2004-04-22
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I. PEDIATRICHospiraN-018920 DISCN2000-09-21
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Tradename
Company
Number
Date
Products
M.V.I. ADULTHospiraN-021625 DISCN2004-01-30
1 products, RLD
M.V.I. ADULT (PHARMACY BULK PACKAGE)HospiraN-021643 DISCN2004-02-18
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
VITAPEDHospiraN-020176 DISCN1993-12-29
1 products
Hide discontinued
Ferrous sulfate
+
Folic acid
Tradename
Company
Number
Date
Products
FOLVRONLederle LaboratoriesN-006012 DISCN1982-01-01
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 LYOPHILIZEDTeligentN-018933 DISCN1985-08-08
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
2 pack assured instant hand sanitizer with moisturizers (vitamin e and aloe)OTC monograph not final2014-11-02
3 hand sanitizersOTC monograph not final2014-11-15
3 pack assured instant hand sanitizer with moisturizers (vitamin e and aloe)OTC monograph not final2014-11-02
3 pack assured instant hand sanitizer with moisturizers (vitamin e and moisturizers)OTC monograph not final2014-11-02
3 pack family dollar instant hand sanitizersOTC monograph not final2014-11-28
adult infuvite multiple vitaminsNew Drug Application2019-05-14
adult infuvite multiple vitamins for infusion pharmacy bulkNew Drug Application2013-01-01
advance hand sanitizer moisturizing formula with aloe and vitamin eOTC monograph not final2020-01-01
altrufuel hand sanitizer with vitamin e and aloe vera moisturizing formulaOTC monograph not final2020-05-22
animi-3unapproved drug other2013-02-06
Show 337 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
folic acid deficiencyEFO_0001070D005494E53.8
megaloblastic anemiaHP_0001889D000749D53.1
hypercholesterolemiaHP_0003124D006937—
hypophosphatemiaHP_0002148D017674—
hypertriglyceridemiaEFO_0004211D015228—
peripheral vascular diseasesEFO_0003875D016491I73.9
dermatitisHP_0011123D003872L30.9
alcoholic neuropathyEFO_1000803D020269G62.1
common coldEFO_0007214D003139J00
seizuresHP_0002069D012640G40.4
Show 26 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B03: Antianemic preparations
— B03A: Iron antianemic preparations
— B03AD: Iron in combination with folic acid
— B03AD01: Ferrous amino acid complex and folic acid
— B03AD02: Ferrous fumarate and folic acid
— B03AD03: Ferrous sulfate and folic acid
— B03AD04: Ferric oxide polymaltose complexes and folic acid
— B03AD05: Ferrous gluconate and folic acid
— B03AE: Iron in other combinations
— B03AE01: Iron, vitamin b12 and folic acid
— B03AE02: Iron, multivitamins and folic acid
— B03B: Vitamin b12 and folic acid
— B03BB: Folic acid and derivatives as antianemics
— B03BB01: Folic acid
— B03BB51: Folic acid, combinations
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01B: Antimetabolites
— L01BA: Folic acid analogs, antimetabolites
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CX: Other diagnostic agents in atc
— V04CX02: Folic acid
HCPCS
No data
Clinical
No data
Drug
General
Drug common nameFolic acid
INNfolic acid
Description
Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing and storage. Folate is required for the body to make DNA and RNA and metabolise amino acids necessary for cell division. As the human body cannot make folate, it is required in the diet, making it an essential nutrient. It occurs naturally in many foods. The recommended adult daily intake of folate in the U.S. is 400 micrograms from foods or dietary supplements.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Nc1nc(=O)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2[nH]1
Identifiers
PDB—
CAS-ID59-30-3
RxCUI—
ChEMBL IDCHEMBL1622
ChEBI ID27470
PubChem CID6037
DrugBankDB00158
UNII ID935E97BOY8 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SLC46A1
SLC46A1
SLC19A1
SLC19A1
Organism
Homo sapiens
Gene name
SLC46A1
Gene synonyms
G21, HCP1, PCFT
NCBI Gene ID
113235
Protein name
proton-coupled folate transporter
Protein synonyms
Heme carrier protein 1, PCFT/HCP1, solute carrier family 46 (folate transporter), member 1, Solute carrier family 46 member 1
Uniprot ID
Q96NT5
Mouse ortholog
Slc46a1 (52466)
proton-coupled folate transporter (Q9D1P1)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Folic acid
+
Cholecalciferol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Folic acid
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
No data
Safety
Black-box Warning
Black-box warning for: Chromagen, Citranatal, Citranatal 90 dha, Citranatal assure, Citranatal b-calm, Citranatal dha, Citranatal essence, Citranatal harmony, Citranatal harmony 2.1, Citranatal harmony 3.0, Citranatal medley, Citranatal rx, Enlyte, Ferralet 90, Healthy mamabe well rounded, Hematogen fa, Hematogen forte, Irospan 24/6, Marnatal f, Menatrol, Moms choice rx, Natafort, Nestabs, Nestabs dha, Nestabs one, Niferex, O-cal prenatal vitamin, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-dha, Pnv-omega, Pnv-select, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Pre-tabs dha, Prenaissance, Prenaissance plus, Prenata, Prenatal plus multivitamin plus dha minicaps, Prenatal plus vitamins, Prenatal vitamins plus low iron, Prenate am, Prenate dha, Prenate elite, Prenate enhance, Prenate essential, Prenate mini, Prenate pixie, Prenate restore, Prenatrix, Prenatryl, Prenatryl prometa, Pretrate, Primacare, Prometa, Select ob, Select-ob plus dha, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha
Adverse Events
0 adverse events reported
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